个人简历

苏敏 教授 博士 博士生导师，贵州省省管专家，优秀青年科技人才，贵州医科大学组织工程与干细胞实验中心主任

电子邮件：sumin@gmc.edu.cn

教育经历：

2011.09-2015.07，贵州医科大学（原贵阳医学院），病理学与病理生理学，博士

1998.09-2001.07，贵阳医学院，人体解剖与组织胚胎学，硕士

1989.09-1994.07，贵阳医学院，临床医学系，学士

工作经历：

2021.01-至今,贵州医科大学，组织工程与干细胞实验中心,教授

2016.09-2018.11，University of Connecticut，Allied Health Science，博士后研究员

2014.8-2021.01，贵州医科大学(原贵阳医学院)，基础医学院，教授

2013.01-2014.08，University of Connecticut，Allied Health Science，访问学者

2010.12-2013.01，贵阳医学院，基础医学院，教授

2004.12-2010.12，贵阳医学院，基础医学院，副教授

1999.12-2004.12，贵阳医学院，基础医学院，讲师

1994.09-1999.12，贵阳医学院，基础医学院，助教

研究方向

主要利用干细胞技术、基因工程技术和生物信息学筛选从事自身免疫病和抗肿瘤免疫治疗及相关机制研究。（1）利用干细胞移植技术，胚胎干细胞分化为胸腺上皮祖细胞，移植重建胸腺结构和功能，诱导免疫耐受，防治自身免疫病发病及相关机制研究。（2）利用生物信息学筛选B7家族相关分子，通过重组蛋白和单克隆抗体技术等，靶向负性调节T细胞或巨噬细胞功能研究，为自身免疫病和抗肿瘤免疫治疗药物筛选提供新的靶点。

项目成果

(1) 国家自然科学基金委员会，面上项目，82171343，新B7相关分子ERMAP(BTN5)调节T细胞和巨噬细胞反应在EAE中作用机制研究，2022.01-2025.12，55万元，在研，主持

(2) 国家自然科学基金委员会，地区科学基金项目，82060151，异源性mESC.TEPs胸腺内移植诱导耐受改善NOD小鼠T1D相关机制研究，2021.01-2024.12，35万元，在研，主持

(3) 贵州省科技厅，科技支撑计划，黔科合支撑[2020]4Y230号，BTN2A2负性调节T细胞功能治疗自身免疫病及相关机制研究，2021.01-2023.12，40万元，在研，主持

(4) 贵州省科技厅，平台人才计划，黔科合平台人才[2020]4103号，自身免疫病治疗及相关机制研究国际科技合作基地，2020.05-2023.05，50万元，在研，主持

(5) 贵州省科技厅，科技支撑计划（黔科合支撑[2017]2970号），高通量基因测序技术及干细胞技术为基础的精准医学在单基因遗传病与自身免疫病诊断和防治中的应用技术研究，2017.07-2020.06，80万元，结题，主持

(6) 国家自然科学基金委员会，地区科学基金项目，8156021，胚胎干细胞来源的胸腺上皮祖细胞表达MOG治疗多发性硬化症的实验研究，2016.01-2019.12，46.8万元，结题，主持

教学情况

承担临床医学本科、协和班、留学生教学和相关专业研究生教学工作。

论文、专著及专利等

[1] He X, Hu R, Luo P, Gao J, Yang W, Li J, Huang Y, Han F, Lai L,Su M. BTN2A2 protein negatively regulates T cells to ameliorate collagen-induced arthritis in mice. Sci Rep. 2021 Sep 29;11(1):19375. doi: 10.1038/s41598-021-98443-5. PMID: 34588505; PMCID: PMC8481265.

[2] Liu H, Zhao J, Su M, Tian X, Lai L. Recombinant CD300c.Fc fusion protein attenuates collagen.induced arthritis in mice. Rheumatology (Oxford). 2021 May 21: keab450. doi: 10.1093/rheumatology/keab450. Online ahead of print. (IF: 7.580)

[3] Lin Y, Cui C, Su M, Silbart LK, Liu H, Zhao J, He L, Huang Y, Xu D, Wei X, Du Q, Lai L.Identification of TAPBPL as a novel negative regulator of T.cell function.EMBO Mol Med. 2021 May 7;13(5):e13404. doi: 10.15252/emmm.202013404. Epub 2021 May 3. (IF: 12.137)

[4] Zhao J, Su M, Lin Y, Liu H, He Z, Lai L. Administration of Amyloid Precursor Protein Gene Deleted Mouse ESC.Derived Thymic Epithelial Progenitors Attenuates Alzheimer's Pathology. Front Immunol. 2020 Aug 11; 11: 1781. doi: 10.3389/fimmu.2020.01781. (IF: 7.561)

[5] Su M, Lin Y, Cui C, Tian X, Lai L. ERMAP is a B7 family.related molecule that negatively regulates T cell and macrophage responses. Cell Mol Immunol. 2020 Jul 3. doi: 10.1038/s41423.020.0494.8. Online ahead of print. (IF: 11.530)

[6] YingXin, Jie Gao, Rong Hu, Hong Li, Qian Li, Feng Han*, Zhixu He, Laijun Lai,Min Su*. Changes of Immune Parameters of T Lymphocytes and Macrophages in EAE Mice after BM.MSCs Transplantation. Immunology Letter. 2020 (IF: 3.658)

[7] Su M, Lin Y, He Z, Lai L.Transplantation of MHC.mismatched mouse embryonic stem cell.derived thymic epithelial progenitors and MHC.matched bone marrow prevents autoimmune diabetes.Stem Cell Res Ther. 2019 Aug 6;10(1):239. doi: 10.1186/s13287.019.1347.1. PMID: 31387620.(IF: 6.832)

[8] Lin Y, Cui C,Su M, Tian X, Huang Y, Zhao J, Lai L.Skint8, a Novel B7 Family.Related Molecule, Negatively Regulates T Cell Responses.J Immunol. 2019 Jul 15;203(2):400.407. doi: 10.4049/jimmunol.1800639. Epub 2019 Jun 12. PMID: 31189570.(IF: 5.422)

[9] Tian X, Lin Y, Cui C,Su M, Lai L.BTNL2.Ig Protein Attenuates Type 1 Diabetes in Non.Obese Diabetic (NOD) Mice.Adv Healthc Mater. 2019 May;8(9): e1800987. doi: 10.1002/adhm.201800987. Epub 2019 Mar 18. PMID: 30884196 (IF: 9.933)

[10] Min Su, Rong Hu, Yinhong Song, Yalan Liu and Laijun Lai.Targeted deletion of c.Met in thymic epithelial cells leads to an autoimmune phenotype.Immunology & Cell Biology, 2018 Feb;96(2):229.235. （IF:5.126）

[11] Cui C,Su M, Lin Y, Lai L.A CD300c.Fc Fusion Protein Inhibits T Cell Immunity.Front Immunol. 2018 Nov 15; 9:2657. doi: 10.3389/fimmu.2018.02657. eCollection 2018. PMID: 30498497. (IF: 7.561)

[12] Cui C, Tian X, Lin Y,Su M, Chen Q, Wang SY, Lai L.In vivo administration of recombinant BTNL2.Fc fusion protein ameliorates graft.versus.host disease in mice.Cell Immunol. 2019 Jan; 335:22.29. doi: 10.1016/j.cellimm.2018.10.008. Epub 2018 Oct 26. PMID: 30389093. (IF: 4.868)

[13] Min Su, Yujun Lin, Cheng Cui, Xiaohong Tian, Xiuling Lu, Zhixu He, and Laijun Lai. ESC.derived thymic epithelial cells expressing MOG prevents EAE by central and peripheral tolerance mechanisms. Cellular Immunology, 2017,322 (2017) 84–91. (IF 4.868)

[14] Feng Han, Rong Hu (co.first author),Min Su,Yanni Yu, Hua Yang, Laijun Lai. A human recombinant IL.7/HGFβ hybridcytokine enhances antitumor immunity in mice. Am J Cancer Res 2017;7(8):1714.1723. (IF：6.166)

[15] Hu R, Liu Y, Song Y,Su M, Liu X, Rood D, and Lai L. Recombint IL.7/HGF b hybrid cytokine separates acute graft.versus.host.disease from graft.versus.tumour activity by altering donor T cell trafficking. Br J Haematol. 2016 Jul 22. doi: 10.1111/bjh.14268. PMID: 27447780（IF:6.998）

[16] Yinhong Song, Yalan Liu, Rong Hu,Min Su, Debra Rood, and Laijun Lai. In Vivo Antitumor Activity of a Recombinant IL7/IL15 Hybrid Cytokine in Mice. Molecular Cancer Therapeutics. July 29, 2016; DOI: 10.1158/1535.7163.MCT.16.0111 (IF: 6.261)

[17] Rong Hu, Yalan Liu,Min Su, Yinhong Song, Debra Rood, Laijun Lai. Transplantation of Donor.Origin Mouse Embryonic Stem Cell.Derived Thymic Epithelial Progenitors Prevents the Development of Chronic Graft.Versus.Host Disease in Mice. Stem Cells Translational Medicine 2016; 5:1.10 (IF:6.940)

[18] Yinhong Song,Min Su,Jing Zhu, Wen Di, Yalan Liu, Rong Hu, Debra Rood, Laijun Lai. FOXN1 recombinant protein enhances T.cell regeneration after hematopoietic stem cell transplantation in mice.Eur J Immunol,2016 Jun;46(6):1518.28.（IF:5.532）

[19] Min Su, Yinhong Song, Zhixu He, Rong Hu, Debra Rood, Laijun Lai. Administration of embryonic stem cell.derived thymic epithelial progenitors expressing MOG induces antigen.specific tolerance and ameliorates experimental autoimmune encephalomyelitis Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells. Journal of Autoimmunity,2015,58:36.47.（IF: 7.094）.

[20] Min Su, Rong Hu, Jingjun Jin, Yuan Yan, Yinhong Song, Ryan Sulivan and Laijun Lai. Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells. Scientific Reports,2015; 5: 9882.；DOI: 10.1038/srep09882（IF:4.379）.

[21] Yinhong Song,Min Su, Pranau Panchatsharam, Debra Rood, Laijun Lai. c.Met signalling is required for efficient postnatal thymic regeneration and repair. Immunology, 2015,144:245.253.（IF:7.397）

[22] Yuan Yan,Min Su, Yinhong Song, Yong Tang, Xiuchun (Cindy) Tian, Debra Rood, and Laijun Lai. Tbx1 Modulates Endodermal and Mesodermal Differentiation from Mouse Induced Pluripotent Stem Cells. STEM CELLS AND DEVELOPMENT, 2014 Jul 1;23(13):1491.500. doi: 10.1089/scd.2013.0488. Epub 2014 Apr 2. (IF:3.272)