个人简历
喻超 教授 博士 主任医师 贵州省肝胆胰脾疾病研究所副所长 贵州医科大学附属医院肝胆外科副主任(主持工作)
电子邮件:yuxchao2002@163.com
教育经历:
2012.09-2015.07,贵州医科大学,病理学与病理生理学,博士
2003.09-2006.07,贵阳医学院,外科学,硕士
1998.09-2003.07,贵阳医学院,临床医学系,学士
工作经历:
2021.02-至今,贵州省肝胆胰脾疾病研究所副所长
2020.02-2020.03,湖北鄂州雷山医院,党支部书记/医疗组长
2020.06-至今,贵州医科大学附属医院外科,第一党支部,支部书记
2019.08-至今,贵州医科大学附属医院,肝胆外科,副主任(主持工作)
2017.12-至今,贵州医科大学,教授
2016.12-至今,贵州医科大学附属医院,肝胆外科,主任医师
2012.12-2016.12,贵阳医学院附属医院,肝胆外科,副主任医师
2009.12-2012.12,贵阳医学院附属医院,肝胆外科,主治医师
2006.09-2009.12,贵阳医学院附属医院,肝胆外科,住院医师
研究方向
胰腺癌侵袭转移分子机制和基因治疗的相关研究:
采用生物化学、细胞生物学、分子生物学、基因组学、蛋白组学、代谢组学等方法及其他研究方法,在细胞和分子水平上探讨胰腺癌侵袭转移的分子机制。利用当前迅速发展的分子生物学、蛋白质组学、表观遗传学及体外细胞和组织工程等新技术,为进一步靶向治疗胰腺癌打下重要的理论与实践基础。所进行的关于胰腺癌侵袭转移分子机制及基因治疗的相关探索性研究,具有极强的开创性,达国际先进、国内领先水平。
项目成果
(1) 贵州省科学技术基金,黔科合支撑[2021]一般080,CDCA7通过与MCM3相互作用介导胰腺癌发生发展的机制研究,2021.4.-2023.3,30万元,在研,项目负责人
(2) 国家自然科学基金,NO.81860506,缺氧微环境下RHBDL2与N1ICD相互作用激活Notch信号通路促进胰腺癌细胞侵袭转移,2019.01-2022.12,34.8万元,在研,项目负责人
(3) 国家自然科学基金,NO.81660483,miR-138-5p调控SIRT1-FOXO1-Rab7通路抑制缺氧诱导的胰腺癌细胞自噬和侵袭转移,2017.01-2020.12,42万元,已结题,项目负责人
(4) 贵州省科学技术基金,黔科合LH字[2016]7229号,缺氧诱导因子HIF-3α促进胰腺癌细胞侵袭转移及机制研究,2016.10-2018.10,7万元,已结题,项目负责人
(5) 贵州省科学技术基金,黔科合J字[2015] 2013号,慢病毒介导的miR-138-5p诱导胰腺癌干细胞去"干性"化的机制研究,2015.06-2018.06,10万元,已结题,项目负责人
(6) 国家国际科技合作专项,2014DFA31420,缺氧诱导miRNAS调控胰腺癌侵袭转移,2014.01-2017.01,已结题,项目主要成员
获奖
(1) 喻超,中华人民共和国国务院,国务院特殊津贴获得者,2020
(2) 喻超,贵州省委组织部,贵州省第十五届青年科技奖,2019
(3) 喻超,全国多中心研究《中国胰腺囊性肿瘤外科诊治现状分析2551例报告》,中国科学技术协会,中国科协第四届优秀论文奖,2019
(4) 喻超,新型研究生培养模式的探索与实践,贵州省科技厅,贵州省研究生教学成果奖,二等奖,2015
(5) 喻超,《Has-microRNA-138-5P靶向调控FOXC1和Vimentin抑制胰腺癌细胞增殖及侵袭转移》,贵州医科大学,贵州医科大学优秀博士论文奖,一等奖,2015
教学情况
至2021年6月共培养博士1人(在读),硕士9人(7人在读)。至2020年6月承担本科生教学及研究生教学总计28课时,其中本科生教学教授胆道疾病,感染;研究生教学教授原发性肝癌的诊治进展与手术讲解,胰腺癌的诊治进展与手术讲解。
论文、专著及专利等
1.期刊论文:
[1] Lin Li#, zhiwei He# Changhao Zhu# Shiyu Chen,Zhehao Yang,Jing Xu,NingruiBi,Chao Yu*,Chengyi Sun*,MiR-137 promotes anoikis through modulating the AKT signaling pathways in Pancreatic Cancer,Journal of Cancer,2020;11(21):6277-6285
[2] BiN#,Sun Y,Lei S,Zeng Z, Zhang Y,Sun C*,Yu Chao*,Identification of 40S ribosomal protein S8 as a novel biomarker for alcohol-associated hepatocellular carcinoma using weighted gene co-expression network analysismiR-18a-5p,Oncology Report,2020;44: 611-627
[3] He Z#, Guo X, Tian S, Zhu C, Chen S,Chao Yu*,Jianxin Jiang*,Chengyi Sun*,MicroRNA-137 reduces stemness features of pancreatic cancer cells by targeting KLF12,J Exp Clin Cancer Res,2019;38(1):126
[4] Yu Chao#, Chen S#, Guo Y, Sun C*,Oncogenic TRIM31 confers gemcitabine resistance in pancreatic cancer via activating the NF-κB signaling pathway,Theranostics,2018;8(12):3224-36
[5] Guo Y, Chen L, Sun C*,Yu Chao*,MicroRNA-500a promotes migration and invasion in hepatocellular carcinoma by activating the Wnt/β-catenin signaling pathway,Biomed Pharmacother,2017;91:13-20
[6] Tian S#, Guo X,Yu Chao#, Jianxin Jiang*.Sun C*,miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1,Oncotarget,2017;8(7):11071-82
[7] Yu C#,Wang M,Chen M,Huang Y,Jiang J*,Upregulation of microRNA-138-5p inhibits pancreatic cancer cell migration and increases chemotherapy sensitivity,Mol Med Rep,2015,12(4):5135-5140.
[8] Chao Yu#,Sheng‑Li Yang.Xiefan Fang.Jian‑Xin Jiang*.Cheng‑Yi Sun*.Tao Huang,Hypoxia disrupts the expression levels of circadian rhythm genes in hepatocellular carcinoma,Mol Med Rep,2015.11(5):4002-8
[9] Chen Z#, Ma Y, Pan Y, Zhu H,Yu Chao*, Sun C*,MiR-1297 suppresses pancreatic cancer cell proliferation and metastasis by targeting MTDH,Mol Cell Probes,2018;40:19-26
[10] Chao Yu#, Min Wang#, Zhipeng Li Jie Xiao, Feng Peng, Xingjun Guo, Yazhu Deng.Jianxin Jiang* .Chengyi Sun*,MicroRNA-138-5p regulates pancreatic cancer cell growth through targeting FOXC1. Cell Oncol (Dordr),2015.38(3):173-81
[11] Yu C#, Zhan L,Jiang J, Pan Y,Zhang H, Li X,Pen F,Wang M,Qin R,Sun C*.KAP-1 is overexpressed and correlates with increased metastatic ability and tumorigenicity in pancreatic cancer,Med Oncol,2014;31(7):25
[12] Yang SL#,Yu C#,Jiang JX*,Liu LP*, Fang X,Wu C,Hepatitis B virus X protein disrupts the balance of the expression of circadian rhythm genes in hepatocellular carcinoma,Oncol Lett,2014.8(6): 2715-2720
[13] Chen Z#,Yu C, Zhan L, Pan Y, Chen L and Sun C*,LncRNA CRNDE promotes hepatic carcinoma cell proliferation, migration and invasion by suppressing miR-384,AM J CANCER RES,2016; 6(10):2299-2309
[14] Jiang JX#, Sun CY*, Tian S,Yu C, Chen MY and Zhang H,Tumor suppressor Fbxw7 antagonizes WNT signaling by targeting beta -catenin for degradation in pancreatic cancer,Tumour Biol,2016; 37(10):13893-13902
[15] Jiang J#, Tian S,Yu C, Chen M and Sun C*,TRIM37 promoted the growth and migration of the pancreatic cancer cells,Tumour Biol,2016; 37(2):2629-2634.
[16] Jiang JX#, Sun CY*, Tian S,Yu C, Chen MY, Zhang H,Tumor suppressor Fbxw7 antagonizes WNT signaling by targeting β-catenin for degradation in pancreatic cancer,Tumour Biol,2016 Aug 3.
[17] Zhang H#,Yu C,Chen M,LiZ,Tian S,Jiang J*,Sun C*,miR-522 contributes to cell proliferation of hepatocellular carcinoma by targeting DKK1 and SFRP2,Tumour Biol,2016 Aug;37(8):11321-9.
[18] (18)Jianxin Jiang#,Zhu Li,Chao Yu,Se Tian,Chengyi Sun*,MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 inhuman pancreatic cancer,Cancer Letters,2015,356(2,Part B):962-970
[19] Jiang J#,Yu C,Chen M, Zhang H, Tian S, Sun C*,Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype,Oncotarget,2014,6(5):2767-2778
[20] Li Z#,Li X,Yu C, Wang M,Peng F, Xiao J,Tian R,Jiang J*, Sun C*,MicroRNA-100 regulates pancreatic cancer cells growth and sensitivity to chemotherapy through targeting FGFR3,Tumour Biol,2014 Dec;35(12):11751-9
[21] Jiang JX#,Gao S,Pan YZ,Yu C,Sun CY*,Overexpression of microRNA-125b sensitizes human hepatocellular carcinoma cells to 5-fluorouracil through inhibition of glycolysis by targeting hexokinase II,Mol Med Rep,2014 Aug;10(2):995-1002
2.会议论文:
脾脏与门静脉高压学组继续教育分会场,脾脏与门静脉高压外科热点、焦点与难点门静脉高压症的微创外科治疗,中国外科周中华医学会、中华医学会外科学分会,2019.10.18,四川成都,专题发言
3.授权发明专利:
(1)喻超,一种普外科伤口扩张装置,2020.02.28,中国,201920684270.7
(2)喻超,一种普外科手术辅助装置,2020.03.06,中国,20192068484541.9