
个人简历
田已申,副教授,博士,微流控实验室负责人
电子邮件:tianyishen@gmc.edu.cn
教育经历:
2019.09-2022.06,武汉大学,化学生物学专业,博士
2015.09-2018.06,青岛科技大学,物理化学专业,硕士
2009.09-2013.06,河北大学,化学教育学专业,学士
工作经历:
2023.09-至今,贵州医科大学,组织工程与干细胞实验中心,副教授
2022.08-2023.9,贵州医科大学,转化医学研究中心,讲师
研究方向
化学偶联与微流控技术在过继细胞治疗中的应用,特别是基于液滴微流控和微流控流体动力学聚焦构建凝胶液滴与脂质体用于嵌合抗原受体细胞的治疗。
项目成果
(1) 贵州省科学技术厅,黔科合基础-ZK[2024]一般133,抗嗜乳脂蛋白2A2凝胶液滴诱导T细胞高浸润治疗胰腺癌的研究,2024.04.01-2027.03.31,10万元,主持。
(2) 贵州省卫生健康委,gzwkj2024-069,基于微流控人工抗原呈递凝胶液滴体外低分化增殖T细胞的研究,2024.01.01-2025.12.31,4万元,主持。
(3) 贵州省教育厅,黔教技(2022)198号,斑基于液滴微流控体外高效扩增低分化免疫细胞的研究, 2023.01-2024.12,5万元,已结题,主持。
教学情况
承担基础医学专业本科生课程《组织学与胚胎学》。
论文、专著及专利等
[1]Y.S. Tian, J. Li, N. Yang, Y. Zhao, J. Zuo, H. Xiong, Y. Pan, L. Xiao, M. Su, F. Han,Integrated microfluidics-based construction of anti-BTN2A2 gel droplet cell preparations for non-invasive tumor-infiltrating lymphocyte therapy, Materials Today Bio 31 (2025) 101545.(中科院一区)(IF:8.7)
[2]Y.S. Tian,W. Chen, G. Du, J. Gao, Y. Zhao, Z. Wang, M. Su, R. Hu, F. Han, Microfluidic-based preparation of artificial antigen-presenting gel droplets for integrated and minimalistic adoptive cell therapy strategies, Biofabrication 16(2) 025034 (2024)(中科院一区)(IF:9.1)
[3]Y.S. Tian, R. Hu, G.S. Du, N. Xu,Microfluidic Chips: Emerging Technologies for Adoptive Cell Immunotherapy, Micromachines14(4) (2023).(中科院一区)(IF:7.2)
[4] Y.S. Tian, K. Wang, C.M. Xu, J. Feng, Z.L. Zhang, Non-invasive T cells Adoptive Immunotherapy for Solid Tumor with Gel Anti-tumor T-cell Injections, Chemical Engineering Journal. 439(2022) 135839.(中科院一区)(IF:15.2)
[5]Y.S. Tian, C.M. Xu, J. Feng, Y.Y. Huangfu, K. Wang, Z.L. Zhang, Personalized gel-droplet monocyte vaccines for cancer immunotherapy, Lab on a Chip 21(22) (2021) 4414-4426.(Hot article)(中科院一区)(IF:8.4)
[6]Y.S. Tian, C. Xin, S. Liu, Y. Liu, S.F. Liu, Affinity Binding-Induced Hg2+ Release and Quantum Dot Doping for General, Label-Free, and Homogenous Fluorescence Protein Assay, ACS Sens. 3(7) (2018) 1401-1408.(中科院一区)(IF:8.1)
[7]Y.S. Tian, L.J. Hao, C. Wang, X.Y. Yang, S.F. Liu, Quantum Dot Doping-Induced Photoluminescence for Facile, Label-Free, and Sensitive Pyrophosphatase Activity Assay and Inhibitor Screening, Nanomaterials 9(1) (2019) 10.(中科院二区)(IF:5.3)
[8]Y.S. Tian, S.S. Zhang, L. Wang, S.F. Liu, A Modular Nanoswitch for Mix-and-Detect Protein Assay Based on Binding-Induced Cascade Dissociation of Kissing Complex, Chembiochem 19(7) (2018) 716-722.(中科院二区)(IF:3.0)
[9]J. Feng, C.M. Xu, H.F. Xia, H.M. Liu, M. Tang,Y.S. Tian, G. Chen, Z.L. Zhang, Three-Dimensional Magnetic Chip with Extracorporeal Circulation for Circulating Tumor Cell In Vivo Detection and Tumor Growth Inhibition, Analytical Chemistry 95(22) (2023) 8735-8743.(中科院一区)(IF:5.7)
[10]K. Wang, K.H. Deng,Y.S. Tian, M.Y. Sun, Z.L. Yu, Z.Q. Tian, Z.L. Zhang, Core/Shell-Structured Ag2Te/Ag2Se Quantum Dots for High-Resolution In Vivo Fluorescence Imaging in the Near Infrared IIb Region, Acs Applied Nano Materials 6(15) (2023) 14289-14299.(中科院二区)(IF:4.7)
[11]Y.J. Yang, Y.Y. Bai, Y.Y. Huangfu, X.Y. Yang,Y.S. Tian, Z.L. Zhang, Single-Nanoparticle Collision Electrochemistry Biosensor Based on an Electrocatalytic Strategy for Highly Sensitive and Specific Detection of H7N9 Avian Influenza Virus, Analytical Chemistry 94(23) (2022).(中科院一区)(IF:5.7)
[12]S.F. Liu, L. Fang,Y.S. Tian, W.J. Wei, L. Wang, Label-free, non-enzymatic and ultrasensitive electrochemical nucleic acid biosensing by tandem DNA-fueled target recycling and hybridization chain reaction, Sens. Actuator B-Chem. 244 (2017) 450-457.(中科院一区)(IF:6.7)
发明专利
1.基于微流控芯片从血液中制备凝胶液滴单核细胞疫苗的装置及方法,张志凌、田已申
专利号:ZL202110172255.6
2.基于微流控芯片T细胞分离与扩增一体化凝胶孵育液滴装置及制作方法,张志凌、田已申
专利号:ZL202111075258.4
3.一种多功能人工抗原呈递凝胶液滴的制备与应用,田已申、胡蓉、苏敏
申请号:202311407851.3
4.一种基于碳二亚胺偶联微流控芯片的多肽水凝胶制备方法,田已申、杨娜、胡蓉、苏敏、杜光石、汪祖利、赵友波
申请号:202510875716.4