个人简历

胡蓉教授博士博士生导师贵州医科大学转化医学研究中心副主任

电子邮件：hurong@gmc.edu.cn

教育经历

2010.09-2013.07，贵阳医学院，病理学与病理生理学，博士

2003.09-2006.07，贵阳医学院，人体解剖与组织胚胎学，硕士

1998.09-2003.07，贵阳医学院，临床医学系，学士

工作经历

2021.05-至今 贵州医科大学，转化医学研究中心，教授

2023.08-2024.08 美国康涅狄格大学，联合健康科学系，博士后研究员

2016.12-至今 贵州医科大学，基础医学院，教授

2014.07-2016.01 美国康涅狄格大学，联合健康科学系，访问学者

2011.12-2016.11， 贵州医科大学（原贵阳医学院），基础医学院，副教授

2008.12-2011.11， 贵阳医学院，基础医学院，讲师

2006.07-2008.12， 贵阳医学院，基础医学院，助教

研究方向

聚焦T细胞发育和功能异常，开展自身免疫病的干细胞和新免疫调节分子治疗研究，以及免疫调节分子为新靶点的肿瘤免疫治疗研究。

项目成果

(1) 国家自然科学基金委员会，地区科学基金项目，82160151, BTN2A2调节T细胞反应在NOD小鼠T1D中的作用及机制研究，2022.01.01-2025.12.31, 34万元，在研,主持

(2) 贵州省科技厅，贵州省科技计划项目，黔科合基础-ZK[2024]重点050，抗-人BTN2A2单抗的开发及其在胶质母细胞瘤免疫治疗中的作用和机制研究，2024.04.01-2028.03.31，30万元，在研，主持

(3) 国家自然科学基金委员会，地区科学基金项目，81660033，供体ESCs源性胸腺上皮祖细胞移植阻止cGVHD的发生及相关免疫耐受机理研究，2017.01.01-2020.12.31，37万元，结题，主持

(4) 贵州省科技厅，贵州省科技计划项目，黔科合基础（2016）1125号，慢性移植物抗宿主病的干细胞治疗研究，2016.10-2019.10，10万元，结题，主持

(5) 贵州省教育厅，贵州省普通高等学校科技拔尖人才支持计划项目，黔教合KY字〔2017〕071号，用mESC-TEPs研究Aire调节免疫耐受的机制，2017-11至2020-10，10万元，结题，主持

教学情况

承担临床医学本科、留学生教学和相关专业研究生教学工作。

论文、专著及专利等

[1] Hu R, Zhao J, Lai KC, Wang S, Zheng J, Stoddard C, Lai L. CHD7 regulates definitive endodermal and mesodermal development from human embryonic stem cells. Stem Cell Res Ther. 2025 Jun 17;16(1):311. doi: 10.1186/s13287-025-04437-9.

[2] Tian Y, Li J, Yang N, Zhao Y, Zuo J, Xiong H, Pan Y, Xiao L, Su M, Han F, He Z,Hu R. Integrated microfluidics-based construction of anti-BTN2A2 gel droplet cell preparations for non-invasive tumor-infiltrating lymphocyte therapy. Mater Today Bio. 2025 Feb 4;31:101545. doi: 10.1016/j.mtbio.2025.101545.

[3] Xiao L,Hu R(co.first author), Chen W, Gao J, Zhao Y, Wang Z, Du G, Tian Y, Lai L, Liu L, Su M. An antibody targeting an immune checkpoint molecule BTN2A2 enhances anti-tumor immunity. Neoplasia. 2025 Jul;65:101161. doi: 10.1016/j.neo.

[4] Wu Y, Song W, Su M, He J,Hu R, Zhao Y. The Role of Cholesterol Metabolism and Its Regulation in Tumor Development. Cancer Med. 2025 Apr;14(7):e70783. doi: 10.1002/cam4.70783.

[5] Zhao J,Hu R, Lai KC, Zhang Z, Lai L. Recombinant FOXN1 fusion protein increases T cell generation in old mice. Front Immunol. 2024 Jul 12;15:1423488. doi: 10.3389/fimmu.2024.1423488.

[6] Tian Y, Chen W, Du G, Gao J, Zhao Y, Wang Z, Su M,Hu R, Han F. Microfluidic-based preparation of artificial antigen-presenting gel droplets for integrated and minimalistic adoptive cell therapy strategies. Biofabrication. 2024 Mar 15;16(2). doi: 10.1088/1758-5090/ad2fd4.

[7] Huang Y, Han F, Li J, Li Y, Gao J, Lai L, Luo P, Su M,HuR. BTN2A2-Ig protein inhibits the differentiation of pathogenic Th17 cells and attenuates EAE in mice. Immunol Lett. 2023 Aug;260:58-67. doi: 10.1016/j.imlet.2023.06.009.

[8] Gao J, Ding L, Xin Y, Li Y, He K, Su M,Hu R. Pax6-Induced Proliferation and Differentiation of Bone Marrow Mesenchymal Stem Cells Into Limbal Epithelial Stem Cells. Stem Cells Dev. 2023 Jul;32(13-14):410-421. doi: 10.1089/scd.2022.0249.

[9] He X,Hu R(co.first author), Luo P, Gao J, Yang W, Li J, Huang Y, Han F, Lai L,Su M. BTN2A2 protein negatively regulates T cells to ameliorate collagen-induced arthritis in mice. Sci Rep. 2021 Sep 29;11(1):19375. doi: 10.1038/s41598-021-98443-5. PMID: 34588505; PMCID: PMC8481265.

[10] Xin Y, Gao J,Hu R, Li H, Li Q, Han F, He Z, Lai L, Su M. Changes of immune parameters of T lymphocytes and macrophages in EAE mice after BM-MSCs transplantation. Immunol Lett. 2020 Sep;225:66-73. doi: 10.1016/j.imlet.2020.05.005.

[11] Su M,Hu R, Song Y, Liu Y, Lai L. Targeted deletion of c-Met in thymic epithelial cells leads to an autoimmune phenotype. Immunol Cell Biol. 2018 Feb;96(2):229-235. doi: 10.1111/imcb.1026.

[12] Feng Han,Rong Hu(co.first author),Min Su, Yanni Yu, Hua Yang, Laijun Lai. A human recombinant IL.7/HGFβ hybridcytokine enhances antitumor immunity in mice. Am J Cancer Res 2017;7(8):1714.1723.

[13] Zhang S, Huang J,Hu R, Guo G, Shang X, Wu J. Characterization of a new multifunctional beta-glucosidase from Musca domestica. Biotechnol Lett. 2017 Aug;39(8):1219-1227. doi: 10.1007/s10529-017-2351-0.

[14] Hu R,Liu Y, Song Y,Su M, Liu X, Rood D, and Lai L. Recombint IL.7/HGF b hybrid cytokine separates acute graft.versus.host.disease from graft.versus.tumour activity by altering donor T cell trafficking. Br J Haematol. 2016 Jul 22. doi: 10.1111/bjh.14268.

[15] Yinhong Song, Yalan Liu,Rong Hu,Min Su, Debra Rood, and Laijun Lai. In Vivo Antitumor Activity of a Recombinant IL7/IL15 Hybrid Cytokine in Mice. Molecular Cancer Therapeutics. July 29, 2016; DOI: 10.1158/1535.7163.MCT.16.0111

[16] Hu R, Liu Y, Su M, Song Y, Rood D, Lai L. Transplantation of Donor-Origin Mouse Embryonic Stem Cell-Derived Thymic Epithelial Progenitors Prevents the Development of Chronic Graft-versus-Host Disease in Mice. Stem Cells Transl Med. 2017 Jan;6(1):121-130. doi: 10.5966/sctm.2016-0012.

[17] Song Y, Su M, Zhu J, Di W, Liu Y,Hu R, Rood D, Lai L. FOXN1 recombinant protein enhances T-cell regeneration after hematopoietic stem cell transplantation in mice. Eur J Immunol. 2016 Jun;46(6):1518-28. doi: 10.1002/eji.201546196.

[18] Su M, Song Y, He Z,Hu R, Rood D, Lai L. Administration of embryonic stem cell-derived thymic epithelial progenitors expressing MOG induces antigen-specific tolerance and ameliorates experimental autoimmune encephalomyelitis. J Autoimmun. 2015 Apr;58:36-47. doi: 10.1016/j.jaut.2015.01.002.

[19] Su M,Hu R, Jin J, Yan Y, Song Y, Sullivan R, Lai L. Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells. Sci Rep. 2015 Jun 5;5:9882. doi: 10.1038/srep09882.