个人简历

苏敏，医学博士，三级教授，博导。美国康涅狄格大学博士后，贵州省优秀青年科技人才（2015），贵州省省委联系专家（2023），贵州省政府特殊津贴专家（2024），中国解剖学会常务理事（第十七届）、组织胚胎学分会常务委员，贵州省解剖学会理事长（第八、九届）。主要从事干细胞与自身免疫病研究。主持面上项目（2024，2021）地区基金（2020，2015）等国家自然科学基金4项，以及省部级科研项目10余项。近五年以第一或通讯作者在影响因子大于10的高水平杂志Cellular & Molecular Immunology（IF=22.1, 2021）、Advanced Healthcare Materials（IF=10.0, 2023）、Journal of Neuroinflammation（IF=10.1, 2025）和Small Structures（IF=11.3, 2025）等SCI收录期刊发表论文11篇。此外，以第一发明人获得国家授权发明专利4项。以第一完成人获贵州省科技进步三等奖、贵州医学科技奖一等奖及二等奖，并作为主要参与者获得中华医学会医学科技一等奖。

电子邮件：sumin@gmc.edu.cn

研究领域

主要利用干细胞技术、基因工程技术和生物信息学筛选，从事自身免疫病和抗肿瘤免疫治疗及相关机制研究。（1）利用干细胞移植技术，胚胎干细胞分化为胸腺上皮祖细胞，移植重建胸腺结构和功能，诱导免疫耐受，防治自身免疫病发病及相关机制研究。（2）利用生物信息学筛选B7家族相关分子，通过重组蛋白和单克隆抗体技术等，靶向负性调节T细胞或巨噬细胞功能研究，为自身免疫病和抗肿瘤免疫治疗药物筛选提供新的靶点。

科研项目

1. 国家自然科学基金委员会，面上项目，82471385，新B7家族相关共抑制分子VSIG2负性调节T细胞反应改善EAE的作用机制研究 ，2025.01.01-2028.12.31，49万元，在研，主持

2. 国家自然科学基金委员会，面上项目，82171343，新B7相关分子ERMAP(BTN5)调节T细胞和巨噬细胞反应在EAE中作用机制研究，2022.01-2025.12，55万元， 在研， 主持

3. 贵州省科技厅，科学家工作站，黔科合平台KXJZ[2024]004，干细胞基础研究与转化应用贵州省院士工作站，200万元，主持

4. 贵州省自身免疫病研究科技创新人才团队，黔科合人才CXTD（2025）048，2025-01-01至2027-12-31，35万元，在研，主持

5. 贵州省科技厅项目基础研究计划，重点项目，黔科合基础ZD（2025）065，非组蛋白ERMAP乳酸化修饰机制及其影响M2极化改善EAE的研究，2025.01-2028.12，20万元，在研，主持

6. 国家自然科学基金委员会，地区科学基金项目，82060151，异源性mESC-TEPs胸腺内移植诱导耐受改善NOD小鼠T1D相关机制研究，2021.01-2024.12，35万元，结题，主持

7. 贵州省科技厅，科技支撑计划，黔科合支撑[2020]4Y230号，BTN2A2负性调节T细胞功能治疗自身免疫病及相关机制研究，2021.01-2023.12，40万元，结题，主持

8. 贵州省科技厅，平台人才计划，黔科合平台人才[2020]4103号，自身免疫病治疗及相关机制研究国际科技合作基地，2020.05-2023.05，50万元，结题，主持

9. 贵州省科技厅，科技支撑计划（黔科合支撑[2017]2970号），高通量基因测序技术及干细胞技术为基础的精准医学在单基因遗传病与自身免疫病诊断和防治中的应用技术研究，2017.07-2020.06，80万元，结题，主持

10. 国家自然科学基金委员会，地区科学基金项目，8156021，胚胎干细胞来源的胸腺上皮祖细胞表达MOG治疗多发性硬化症的实验研究，2016.01-2019.12，46.8万元，结题，主持

发表论文

1. Wang X, Hu R, Chen K, He K, Li Y, Gao J, Tian Y, Du G, Wang Z, Zhao Y, Lai L,Su M. VSIG2 as a novel immunosuppressive ligand interacts with Nectin-2 to regulate T cell responses. J Neuroinflammation. 2025 Dec 5. doi: 10.1186/s12974-025-03645-7. Epub ahead of print. PMID: 41350674.

2. Xuan Wang, Zhiqi Hu, Youbo Zhao, Yang Fei, Menghuan Li,Min Su,Zhong Luo,and Rong Hu.Brain‐Targeted Multifunctional Liposomes Reprogram Microglia via Anti‐Inflammatory Signaling and Reactive Oxygen Species Scavenging to Treat Post‐Traumatic Neuroinflammation. SmallStructures.2025 Oct, 6(12).DOI:10.1002/sstr.202500270

3. Wu Y, Song W, Wu X, He J,Su M, Hu R, Zhao Y. The Therapeutic Effect of GPR81 in Autoimmune Hepatitis and Hepatocellular Carcinoma via Regulating the Immune Response. Int J Mol Sci. 2025 Jun 30;26(13):6308. doi: 10.3390/ijms26136308. PMID: 40650086; PMCID: PMC12249850.

4. Xia L, Pan Y, Wang X, Hu R, Gao J, Chen W, He K, Cui D, Zhao Y, Liu L, Lai L,Su M. ERMAP attenuates DSS-induced colitis in mice by regulating macrophage and T cell functions. BMC Gastroenterol. 2025 May 12;25(1):362. doi: 10.1186/s12876-025-03840-z. PMID: 40355813; PMCID: PMC12070682.

5. Xiao L, Hu R, Chen W, Gao J, Zhao Y, Wang Z, Du G, Tian Y, Lai L, Liu L,Su M. An antibody targeting an immune checkpoint molecule BTN2A2 enhances anti-tumor immunity. Neoplasia. 2025 Jul;65:101161. doi: 10.1016/j.neo.2025.101161. Epub 2025 Apr 21. PMID: 40262436; PMCID: PMC12053764.

6. Wu Y, Song W,Su M, He J, Hu R, Zhao Y. The Role of Cholesterol Metabolism and Its Regulation in Tumor Development. Cancer Med. 2025 Apr;14(7):e70783. doi: 10.1002/cam4.70783. PMID: 40145543; PMCID: PMC11948085.

7. He K, Chen K, Hu R, Wen T, Li Y, Xia L, Xiao L, Zhao Y, Cui D, Gao J, Liu L, Lai L,Su M.Endogenous ERMAP Affects T-Cell Function in EAE Mice. Immunology. 2025 Jun;175(2):200-213. doi: 10.1111/imm.13910. Epub 2025 Mar 11. PMID: 40065719.

8. Tian Y, Li J, Yang N, Zhao Y, Zuo J, Xiong H, Pan Y, Xiao L,Su M, Han F, He Z, Hu R. Integrated microfluidics-based construction of anti-BTN2A2 gel droplet cell preparations for non-invasive tumor-infiltrating lymphocyte therapy. Mater Today Bio. 2025 Feb 4;31:101545. doi: 10.1016/j.mtbio.2025.101545. PMID: 40026625; PMCID: PMC11869011.

9. Tian Y, Chen W, Du G, Gao J, Zhao Y, Wang Z,Su M, Hu R, Han F. Microfluidic-based preparation of artificial antigen-presenting gel droplets for integrated and minimalistic adoptive cell therapy strategies. Biofabrication. 2024 Mar 15;16(2). doi: 10.1088/1758-5090/ad2fd4. PMID: 38437712.

10. Zhao Y, Li Y, He J, Li M, Yao X, Yang H, Luo Z, Luo P,Su M. Nanointegrative Glycoengineering-Activated Necroptosis of Triple Negative Breast Cancer Stem Cells Enables Self-Amplifiable Immunotherapy for Systemic Tumor Rejection. Adv Healthc Mater. 2024 Apr;13(9):e2303337. doi: 10.1002/adhm.202303337. Epub 2024 Jan 4. PMID: 38154036.

11. Huang Y, Han F, Li J, Li Y, Gao J, Lai L, Luo P,Su M, Hu R. BTN2A2-Ig protein inhibits the differentiation of pathogenic Th17 cells and attenuates EAE in mice. Immunol Lett. 2023 Aug;260:58-67. doi: 10.1016/j.imlet.2023.06.009. Epub 2023 Jun 25. PMID: 37369312.

12. Gao J, Ding L, Xin Y, Li Y, He K,Su M, Hu R. Pax6-Induced Proliferation and Differentiation of Bone Marrow Mesenchymal Stem Cells Into Limbal Epithelial Stem Cells. Stem Cells Dev. 2023 Jul;32(13-14):410-421. doi: 10.1089/scd.2022.0249. Epub 2023 May 31. PMID: 37097204.

13. He X, Hu R, Luo P, Gao J, Yang W, Li J, Huang Y, Han F, Lai L,Su M. BTN2A2 protein negatively regulates T cells to ameliorate collagen-induced arthritis in mice. Sci Rep. 2021 Sep 29;11(1):19375. doi: 10.1038/s41598-021-98443-5. PMID: 34588505; PMCID: PMC8481265.

14. Liu H, Zhao J,Su M, Tian X, Lai L. Recombinant CD300c.Fc fusion protein attenuates collagen.induced arthritis in mice. Rheumatology (Oxford). 2021 May 21: keab450. doi: 10.1093/rheumatology/keab450. Online ahead of print.

15. Lin Y, Cui C,Su M, Silbart LK, Liu H, Zhao J, He L, Huang Y, Xu D, Wei X, Du Q, Lai L.Identification of TAPBPL as a novel negative regulator of T.cell function.EMBO Mol Med. 2021 May 7;13(5):e13404. doi: 10.15252/emmm.202013404. Epub 2021 May 3.

16. Zhao J,Su M, Lin Y, Liu H, He Z, Lai L. Administration of Amyloid Precursor Protein Gene Deleted Mouse ESC.Derived Thymic Epithelial Progenitors Attenuates Alzheimer's Pathology. Front Immunol. 2020 Aug 11; 11: 1781. doi: 10.3389/fimmu.2020.01781.

17. Su M, Lin Y, Cui C, Tian X, Lai L. ERMAP is a B7 family.related molecule that negatively regulates T cell and macrophage responses. Cell Mol Immunol. 2020 Jul 3. doi: 10.1038/s41423.020.0494.8. Online ahead of print.

18. YingXin, Jie Gao, Rong Hu, Hong Li, Qian Li, Feng Han, ZhixuHe, Laijun Lai,Min Su.Changes of Immune Parameters of T Lymphocytes and Macrophages in EAE Mice after BM.MSCs Transplantation. Immunology Letter. 2020 (IF: 3.658)

19. Su M, Lin Y, He Z, Lai L.Transplantation of MHC.mismatched mouse embryonic stem cell.derived thymic epithelial progenitors and MHC.matched bone marrow prevents autoimmune diabetes.Stem Cell Res Ther. 2019 Aug 6;10(1):239. doi: 10.1186/s13287.019.1347.1. PMID: 31387620.

20. Lin Y, Cui C,Su M, Tian X, Huang Y, Zhao J, Lai L.Skint8, a Novel B7 Family.Related Molecule, Negatively Regulates T Cell Responses.J Immunol. 2019 Jul 15;203(2):400.407. doi: 10.4049/jimmunol.1800639. Epub 2019 Jun 12. PMID: 31189570.

21. Tian X, Lin Y, Cui C,Su M, Lai L.BTNL2.Ig Protein Attenuates Type 1 Diabetes in Non.Obese Diabetic (NOD) Mice.Adv Healthc Mater. 2019 May;8(9): e1800987. doi: 10.1002/adhm.201800987. Epub 2019 Mar 18. PMID: 30884196.

22. Min Su, Rong Hu, Yinhong Song, Yalan Liu and Laijun Lai.Targeted deletion of c.Met in thymic epithelial cells leads to an autoimmune phenotype.Immunology & Cell Biology,2018 Feb;96(2):229.235.

23. Cui C,Su M, Lin Y, Lai L.A CD300c.Fc Fusion Protein Inhibits T Cell Immunity.Front Immunol. 2018 Nov 15; 9:2657. doi: 10.3389/fimmu.2018.02657. eCollection 2018. PMID: 30498497.

24. Cui C, Tian X, Lin Y,Su M, Chen Q, Wang SY, Lai L.In vivo administration of recombinant BTNL2.Fc fusion protein ameliorates graft.versus.host disease in mice.Cell Immunol. 2019 Jan; 335:22.29. doi: 10.1016/j.cellimm.2018.10.008. Epub 2018 Oct 26. PMID: 30389093.

25. Min Su, Yujun Lin, Cheng Cui, Xiaohong Tian, Xiuling Lu, Zhixu He, and Laijun Lai. ESC.derived thymic epithelial cells expressing MOG prevents EAE by central and peripheral tolerance mechanisms. Cellular Immunology, 2017,322 (2017) 84–91. (IF 4.868)

26. Feng Han, Rong Hu (co.first author),Min Su,Yanni Yu, Hua Yang, Laijun Lai. A human recombinant IL.7/HGFβ hybridcytokine enhances antitumor immunity in mice. Am J Cancer Res 2017;7(8):1714.1723.

27. Hu R, Liu Y, Song Y,Su M, Liu X, Rood D, and Lai L. Recombint IL.7/HGF b hybrid cytokine separates acute graft.versus.host.disease from graft.versus.tumour activity by altering donor T cell trafficking. Br J Haematol. 2016 Jul 22. doi: 10.1111/bjh.14268. PMID: 27447780.

28. Yinhong Song, Yalan Liu, Rong Hu,Min Su, Debra Rood, and Laijun Lai. In Vivo Antitumor Activity of a Recombinant IL7/IL15 Hybrid Cytokine in Mice. Molecular Cancer Therapeutics. July 29, 2016; DOI: 10.1158/1535.7163.MCT.16.0111.

29. RongHu, Yalan Liu,Min Su, Yinhong Song, Debra Rood, Laijun Lai. Transplantation of Donor.Origin Mouse Embryonic Stem Cell.Derived Thymic Epithelial Progenitors Prevents the Development of Chronic Graft.Versus.Host Disease in Mice. Stem Cells Translational Medicine 2016; 5:1.10.

30. Yinhong Song,Min Su,Jing Zhu, Wen Di, Yalan Liu, Rong Hu, Debra Rood, Laijun Lai. FOXN1 recombinant protein enhances T.cell regeneration after hematopoietic stem cell transplantation in mice.Eur J Immunol,2016 Jun;46(6):1518.28.

31. Min Su, Yinhong Song, Zhixu He, Rong Hu, Debra Rood, Laijun Lai. Administration of embryonic stem cell.derived thymic epithelial progenitors expressing MOG induces antigen.specific tolerance and ameliorates experimental autoimmune encephalomyelitis Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells. Journal of Autoimmunity,2015,58:36.47.

32. Min Su, Rong Hu, Jingjun Jin, Yuan Yan, Yinhong Song, Ryan Sulivan and Laijun Lai. Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells. Scientific Reports,2015; 5: 9882.；DOI: 10.1038/srep09882 .

33. Yinhong Song,Min Su, Pranau Panchatsharam, Debra Rood, Laijun Lai. c.Met signalling is required for efficient postnatal thymic regeneration and repair. Immunology, 2015,144:245.253.

34. Yuan Yan,Min Su, Yinhong Song, Yong Tang, Xiuchun (Cindy) Tian, Debra Rood, and Laijun Lai. Tbx1 Modulates Endodermal and Mesodermal Differentiation from Mouse Induced Pluripotent Stem Cells. STEM CELLS AND DEVELOPMENT, 2014 Jul 1;23(13):1491.500. doi: 10.1089/scd.2013.0488. Epub 2014 Apr 2.

发明专利

1. VSIG2在制备治疗自身免疫性疾病产品中的应用，专利号：ZL 2023 1 1717187.2。

2. 抗VSIG2 VHH纳米抗体在胰腺癌治疗中的应用，专利号：ZL 2025 1 0867094.0。

3. BTN2A2作为免疫检查点在制备抗肿瘤产品中的应用，已授权。

4. CADM3在制备治疗自身免疫性疾病的产品中的应用，已公开。