个人简历

胡蓉，医学博士，教授，博导。美国康涅狄格大学博士后，贵州省普通高等学校科技拔尖人才。中国解剖学会第十七届理事会医学发育生物学分会委员、第十届贵州省解剖学会秘书长。现主要从事免疫检查点抑制剂开发和应用基础研究。主持国家自然科学基金2项、省级和市厅级科研项目多项，发表SCI收录论文10余篇。近5年以第一或通讯作者发表SCI收录文论10篇，其中影响因子大于10的研究论文2篇。作为主要参与人获2项贵州医学科技奖及多项发明专利。

电子邮件：hurong@gmc.edu.cn

研究方向

免疫检查点抑制剂开发和应用基础研究

科研项目

1. 国家自然科学基金委员会，地区科学基金项目，82160151, BTN2A2调节T细胞反应在NOD小鼠T1D中的作用及机制研究，2022.01.01-2025.12.31, 34万元，在研,主持

2. 贵州省科技厅，贵州省科技计划项目，黔科合基础-ZK[2024]重点050，抗-人BTN2A2单抗的开发及其在胶质母细胞瘤免疫治疗中的作用和机制研究，2024.04.01-2028.03.31，30万元，在研，主持

3. 国家自然科学基金委员会，地区科学基金项目，81660033，供体ESCs源性胸腺上皮祖细胞移植阻止cGVHD的发生及相关免疫耐受机理研究，2017.01.01-2020.12.31，37万元，结题，主持

4. 贵州省科技厅，贵州省科技计划项目，黔科合基础（2016）1125号，慢性移植物抗宿主病的干细胞治疗研究，2016.10-2019.10，10万元，结题，主持

5. 贵州省教育厅，贵州省普通高等学校科技拔尖人才支持计划项目，黔教合KY字〔2017〕071号，用mESC-TEPs研究Aire调节免疫耐受的机制，2017-11至2020-10，10万元，结题，主持

发表论文

1. Tian Y, Li J, Yang N, Zhao Y, Zuo J, Xiong H, Pan Y, Xiao L, Su M, Han F, He Z,Hu R. Integrated microfluidics-based construction of anti-BTN2A2 gel droplet cellpreparations for non-invasive tumor-infiltrating lymphocyte therapy. Mater Today Bio. 2025 Feb 4;31:101545. doi: 10.1016/j.mtbio.2025.101545.

2. Hu R, Zhao J, Lai KC, Wang S, Zheng J, Stoddard C, Lai L. CHD7 regulates definitive endodermal and mesodermal development from human embryonic stem cells. Stem Cell Res Ther. 2025 Jun 17;16(1):311. doi: 10.1186/s13287-025-04437-9.

3. Wang X,Hu R(co.first author), Chen K, He K, Li Y, Gao J, Tian Y, Du G, Wang Z, Zhao Y, Lai L, Su M. VSIG2 as a novel immunosuppressive ligand interacts with Nectin-2 to regulate T cell responses. J Neuroinflammation. 2025 Dec 5. doi: 10.1186/s12974-025-03645-7.

4. Xiao L,Hu R(co.first author), Chen W, Gao J, Zhao Y, Wang Z, Du G, Tian Y, Lai L, Liu L, Su M. An antibody targeting an immune checkpoint molecule BTN2A2 enhances anti-tumorimmunity. Neoplasia. 2025 Jul;65:101161. doi: 10.1016/j.neo.

5. Wu Y, Song W, Su M, He J,Hu R, Zhao Y. The Role of Cholesterol Metabolism and Its Regulation in Tumor Development. Cancer Med. 2025 Apr;14(7):e70783. doi: 10.1002/cam4.70783.

6. Wu Y, Song W, Wu X, He J, Su M,Hu R, Zhao Y. The Therapeutic Effect of GPR81 in Autoimmune Hepatitis and Hepatocellular Carcinoma via Regulating the Immune Response. Int J Mol Sci. 2025 Jun 30;26(13):6308. doi: 10.3390/ijms26136308.

7. Zhao J,Hu R, Lai KC, Zhang Z, Lai L. Recombinant FOXN1 fusion protein increases T cell generation in old mice. Front Immunol. 2024 Jul 12;15:1423488. doi: 10.3389/fimmu.2024.1423488.

8. Tian Y, Chen W, Du G, Gao J, Zhao Y, Wang Z, Su M,Hu R, Han F. Microfluidic-based preparation of artificial antigen-presenting gel droplets for integrated and minimalistic adoptive cell therapy strategies. Biofabrication. 2024 Mar 15;16(2). doi: 10.1088/1758-5090/ad2fd4.

9. Huang Y, Han F, Li J, Li Y, Gao J, Lai L, Luo P, Su M,HuR. BTN2A2-Ig protein inhibits the differentiation of pathogenic Th17 cells and attenuates EAE in mice. Immunol Lett. 2023 Aug;260:58-67. doi: 10.1016/j.imlet.2023.06.009.

10. Gao J, Ding L, Xin Y, Li Y, He K, Su M,Hu R. Pax6-Induced Proliferation and Differentiation of Bone Marrow Mesenchymal Stem Cells Into Limbal Epithelial Stem Cells. Stem Cells Dev. 2023 Jul;32(13-14):410-421. doi: 10.1089/scd.2022.0249.

11. He X,Hu R(co.first author), Luo P, Gao J, Yang W, Li J, Huang Y, Han F, Lai L,Su M. BTN2A2 protein negatively regulates T cells to ameliorate collagen-induced arthritis in mice. Sci Rep. 2021 Sep 29;11(1):19375. doi: 10.1038/s41598-021-98443-5. PMID: 34588505; PMCID: PMC8481265.

12. Xin Y, Gao J,Hu R, Li H, Li Q, Han F, He Z, Lai L, Su M. Changes of immune parameters of T lymphocytes and macrophages in EAE mice after BM-MSCs transplantation. Immunol Lett. 2020 Sep;225:66-73. doi: 10.1016/j.imlet.2020.05.005.

13. Su M,Hu R, Song Y, Liu Y, Lai L. Targeted deletion of c-Met in thymic epithelial cells leads to an autoimmune phenotype. Immunol Cell Biol. 2018 Feb;96(2):229-235. doi: 10.1111/imcb.1026.

14. Feng Han,Rong Hu(co.first author), Min Su, Yanni Yu, Hua Yang, Laijun Lai. A human recombinant IL.7/HGFβ hybridcytokine enhances antitumor immunity in mice. Am J Cancer Res 2017;7(8):1714.1723.

15. Zhang S, Huang J,Hu R, Guo G, Shang X, Wu J. Characterization of a new multifunctional beta-glucosidase from Musca domestica. Biotechnol Lett. 2017 Aug;39(8):1219-1227. doi: 10.1007/s10529-017-2351-0.

16. Hu R, Liu Y, Song Y, Su M, Liu X, Rood D, and Lai L. Recombint IL.7/HGF b hybrid cytokine separates acute graft.versus.host.disease from graft.versus.tumour activity by altering donor T cell trafficking. Br J Haematol. 2016 Jul 22. doi: 10.1111/bjh.14268.

17. Yinhong Song, Yalan Liu,Rong Hu,Min Su, Debra Rood, and Laijun Lai. In Vivo Antitumor Activity of a Recombinant IL7/IL15 Hybrid Cytokine in Mice. Molecular Cancer Therapeutics. July 29, 2016; DOI: 10.1158/1535.7163.MCT.16.0111

18. Hu R, Liu Y, Su M, Song Y, Rood D, Lai L. Transplantation of Donor-Origin Mouse Embryonic Stem Cell-Derived Thymic Epithelial Progenitors Prevents the Development of Chronic Graft-versus-Host Disease in Mice. Stem Cells Transl Med. 2017 Jan;6(1):121-130. doi: 10.5966/sctm.2016-0012.

19. Song Y, Su M, Zhu J, Di W, Liu Y,Hu R, Rood D, Lai L. FOXN1 recombinant protein enhances T-cell regeneration after hematopoietic stem cell transplantation in mice. Eur J Immunol. 2016 Jun;46(6):1518-28. doi: 10.1002/eji.201546196.

20. Su M, Song Y, He Z,Hu R, Rood D, Lai L. Administration of embryonic stem cell-derived thymic epithelial progenitors expressing MOG induces antigen-specific tolerance and ameliorates experimental autoimmune encephalomyelitis. J Autoimmun. 2015 Apr;58:36-47. doi: 10.1016/j.jaut.2015.01.002.

21. Su M,Hu R, Jin J, Yan Y, Song Y, Sullivan R, Lai L. Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells. Sci Rep. 2015 Jun 5;5:9882. doi: 10.1038/srep09882.